Professor Guller has directed a research laboratory for the last 30 years and published more than 100 peer-reviewed papers in the areas of glucocorticoid action, placental pathophysiology in preeclampsia (PE) and intrauterine growth restriction (IUGR), placental immune function, and the biology of extracellular matrix proteins. In the last nine years Professor Guller served on 20 NIH Study Section Panels including Special Emphasis Review Groups, HED-1, and PN Panels, and was a permanent member of the NICHD Obstetrics and Maternal-Fetal Biology Subcommittee from 2013 to 2016.
Professor Guller served on the editorial board of The Journal of Clinical Endocrinology & Metabolism and the advisory board of The American Journal of Obstetrics and Gynecology. He trained approximately 40 fellows, residents and students. The major research focus of his laboratory has been and remains placental pathophysiology and placental-fetal immunology in pregnancies complicated by PE, IUGR, and preterm birth. Professor Guller laboratory’s specific strength is the development of novel culture methodologies and use of human placental-derived primary cell cultures and cell lines including Hofbauer cells (HBCs), cytotrophoblasts, and syncytiotrophoblasts. These methodologies have facilitated recent studies on the role of HBCs in innate immune function. He also have significant experience in analysis of placental mRNA and protein expression in tissues obtained from adverse pregnancy outcomes.
Professor Guller current studies using siRNA and function-perturbing antibodies in the analysis of placental cell function are directed towards elucidating mechanisms regulating responses to infection and broader studies examining the immunology of pregnancy.